Research Archives • Page 11 of 12 • FRAXA Research Foundation

Vladimir Gelfand, PhD, at Northwestern University, FRAXA research grant

Transport, Anchoring and Translation of FMRP-Associated mRNAs

February 15, 2005

FRAXA’s $40K grant supported Dr. Vladimir Gelfand’s Northwestern team in exploring links between mGluR, mRNA, and FMRP.

Reactivating the FMR1 Gene

February 27, 2004

With $171.6K from FRAXA, Dr. Andre Hoogeveen’s Erasmus team developed methods to reactivate the Fragile X gene, advancing curative research.

Holly Cline, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

FMRP Function in the Xenopus Visual System

February 27, 2004

With $75K from FRAXA, Dr. Holly Cline at Cold Spring Harbor studied Fragile X proteins and mRNA regulation in tadpoles.

Fragile X Syndrome and RNAi

February 27, 2004

With $75K from FRAXA, Dr. Richard Carthew at Northwestern studied how RNA interference (RNAi) and FMRP interact in Fragile X.

Clive Svendsen, PhD, at University of Wisconsin, FRAXA research grant

Generating Human Neurons Carrying the Fragile X Mutation

February 26, 2004

FRAXA’s $50K grant supported Dr. Clive Svendsen at Wisconsin in growing Fragile X stem cells to better understand gene characteristics.

Edouard Khandijian, PhD, at Laval University, FRAXA research grant

Xenopus (Frog) Model System of Fragile X and Related Proteins

February 26, 2004

With $50K from FRAXA, Dr. Edouard Khandjian at Laval University studied FMR1 and related genes FXR1 and FXR2 in frog models of Fragile X.

Fruit Fly Helps Reveal the Secrets of Fragile X

February 26, 2004

FRAXA’s $50K grant supported Dr. Bassem Hassan’s Flanders team in using fruit flies to model Fragile X and guide future therapy studies.

Kenneth J. Mack, MD, PhD, at Mayo Clinic, FRAXA research grant

Role of Experience in Regulating Levels of the Fragile X Protein

January 1, 2004

With $49K from FRAXA, Drs. Mack and Todd studied how brain stimulation changes FMRP levels, deepening Fragile X research insight.

David Bloom, PhD, at University of Florida, FRAXA research grant

FMR1 Gene Delivery Using Herpes Simplex Virus Vectors

March 1, 2003

With $89K from FRAXA, Dr. David Bloom’s team advanced Fragile X gene therapy by transferring the fmr1 gene into mouse brains via viral vectors.

Jay Brenman, PhD, at University of North Carolina, FRAXA research grant

Dendritic Spine Formation and Fragile X

February 27, 2003

With $35K from FRAXA, Dr. Jay Brenman at UNC used fruit fly models to study Fragile X and uncover key disease mechanisms.

Jerry Yin, PhD, at University of Wisconsin, FRAXA research grant

DFXR and Synaptic Tagging in Drosophila (Fruit Flies)

February 27, 2003

FRAXA’s $135K grant supported Dr. Jerry Yin’s Fragile X fruit fly studies on memory formation at Wisconsin’s Waisman Center.

Haruhiko Siomi, PhD, at Tokushima University, FRAXA research grant

Understanding the Function of Fragile X Protein in Drosophila

February 26, 2003

FRAXA-funded Tokushima researchers mapped the Drosophila FMR1 gene and its pathways, revealing how Fragile X disrupts cell function.

Assam El-Osta, PhD, at Peter MacCallum Cancer Institute, Australia, FRAXA research grant

FMR1 Repression and the Signals to Chromatin

February 26, 2003

With $70K from FRAXA, Dr. Assam El-Osta’s team at Peter MacCallum Cancer Institute studied FMR1 silencing and histone regulation in Fragile X.

Molecular Basis of Increased Seizure Severity in the Fragile X Knockout Mouse

February 26, 2003

FRAXA’s $50K grant supported Dr. Carl Dobkin’s team in uncovering why Fragile X mice show increased seizure activity. Findings published.

Isolating and Characterizing the mRNAs That Bind FMRP

January 14, 2003

With $60K from FRAXA, Dr. Denman’s team investigated how the Fragile X protein FMRP functions in the brain.

Linda Crnic, PhD, at University of Colorado, FRAXA research grant

Treatment of a Mouse Model of Fragile X Syndrome with MPEP

January 1, 2003

A $49K FRAXA grant helped Dr. Linda Crnic’s Colorado team study chronic MPEP use to ease Fragile X symptoms while preserving cognition.

Structure of FMRP

February 27, 2002

With $68K from FRAXA, Dr. Lynne Regan at Yale studied how protein shapes influence Fragile X function. Results were published.

Prospects For Gene Therapy in the Fragile X

February 27, 2002

FRAXA-funded Dr. Rattazzi explored gene therapy to transfer the FMR1 gene into the brain of Fragile X mice, publishing key results.

Kevin Moses, PhD, Wellcome Trust, FRAXA scientific Advisor

A Genetic Screen For Dominant Modifiers of Drosophila (Fruitfly) FMR

February 27, 2002

A $35K FRAXA grant supported Dr. Kevin Moses at Emory in using fruit flies to screen for genes active in the Fragile X signaling pathway.

Robert Malinow, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Studies of glutamate receptor trafficking

August 1, 2001

With $35K from FRAXA, Drs. Malinow and Zhu at Cold Spring Harbor mapped proteins affected by Fragile X. Dr. Zhu continued this work at UVA.

Prepulse Inhibition in Fragile X

June 27, 2001

With $27K from FRAXA, Dr. Alcino Silva studied prepulse inhibition in Fragile X mice and children, linking lab findings to real-world behavior.

Robert Darnell, MD, PhD, at Rockefeller University, FRAXA research grant

Identification of Specific RNA Targets of FMRP

February 27, 2001

FRAXA-funded Dr. Darnell’s Rockefeller team uncovered how FMRP works and how its absence alters brain function. Published results.

Dr. Eric Kandel, MD, Columbia University, FRAXA research grant

Transgenic Mouse Model Studies of Fragile X Syndrome

February 27, 2001

With $410K from FRAXA, Dr. Eric Kandel’s team at Columbia developed Fragile X mouse models to advance future studies of the disorder.

Startle Modulation in Males with Fragile X Syndrome

February 27, 2001

FRAXA’s $42,720 grant helped Dr. Elisabeth Dykens uncover startle and PPI effects in Fragile X males. Results were published.

Transport, Anchoring and Translation of FMRP-Associated mRNAs

Reactivating the FMR1 Gene

FMRP Function in the Xenopus Visual System

Fragile X Syndrome and RNAi

Generating Human Neurons Carrying the Fragile X Mutation

Xenopus (Frog) Model System of Fragile X and Related Proteins

Fruit Fly Helps Reveal the Secrets of Fragile X

Role of Experience in Regulating Levels of the Fragile X Protein

FMR1 Gene Delivery Using Herpes Simplex Virus Vectors

Dendritic Spine Formation and Fragile X

DFXR and Synaptic Tagging in Drosophila (Fruit Flies)

Understanding the Function of Fragile X Protein in Drosophila

FMR1 Repression and the Signals to Chromatin

Molecular Basis of Increased Seizure Severity in the Fragile X Knockout Mouse

Isolating and Characterizing the mRNAs That Bind FMRP

Treatment of a Mouse Model of Fragile X Syndrome with MPEP

Structure of FMRP

Prospects For Gene Therapy in the Fragile X

A Genetic Screen For Dominant Modifiers of Drosophila (Fruitfly) FMR

Studies of glutamate receptor trafficking

Prepulse Inhibition in Fragile X

Identification of Specific RNA Targets of FMRP

Transgenic Mouse Model Studies of Fragile X Syndrome

Startle Modulation in Males with Fragile X Syndrome

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