Role of Experience in Regulating Levels of the Fragile X Protein

FRAXA Research Grant to Kenneth J. Mack, MD, PhD — Mayo Clinic

with Peter K. Todd, MD, PhD, Postdoctoral Fellow

 

FRAXA Awards:

$29,000 in 2001
$20,000 in 2000

Final Report on Dr. Mack’s Project

While a professor at University of Wisconsin-Madison, Dr. Mack investigated whether and how FMRP levels are regulated in response to neuronal stimulation in vivo (in live animals). He looked at the effects of seizures and of experience in his experiments.

Dr. Mack and colleagues published their findings in the Proceedings of the National Academy of Sciences:

The Fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

Peter K. Todd, Kenneth J. Mack, and James S. Malter

PNAS | November 25, 2003 | vol. 100 | no. 24