Discovering Effective Treatments & A Cure for Fragile X Syndrome

Your support enables FRAXA Research Foundation to fund groundbreaking research and life-changing clinical trials.

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FRAXA's Impact to Date

Read our report for an update on Fragile X research and progress towards a cure.

Explore 30 years of outstanding Fragile X research.

$34.8M

Direct Investment in Fragile X Research

32

Teams Actively Researching Fragile X Syndrome

33

Pharmaceutical and Biomedical Partners

641

Fragile X Research Grants Awarded

How Does FRAXA Help?

FRAXA’s mission is to find effective treatments and ultimately a cure for Fragile X syndrome. We directly fund research grants and fellowships at top universities around the world. We partner with biomedical and pharmaceutical companies, large and small, to bridge the gap between research discoveries and actual treatments.

Treatments for Fragile X are likely to help people affected by autism, Alzheimer’s, and other brain disorders.

What is Fragile X Syndrome?

Fragile X syndrome (FXS) is the most common inherited cause of autism and intellectual disabilities. It affects 1 in 4,000 boys and 1 in 8,000 girls worldwide.

Fragile X syndrome occurs when a single gene on the X chromosome shuts down. This gene makes a protein needed for normal brain development. In FXS it does not work properly, the protein is not made, and the brain does not develop as it should.

The Latest from FRAXA

Tetra Therapeutics Phase 3 Clinical Trial of Zatolmilast in Fragile X Syndrome

Recruiting: Tetra Therapeutics Phase 3 Clinical Trial of Zatolmilast in Fragile X Syndrome

February 29, 2024

Tetra Therapeutics has launched large scale clinical trials of their phosphodiesterase (PDE) inhibitor for males ages 9-45 with Fragile X syndrome. FRAXA Research Foundation’s basic and translational research pointed the way to phosphodiesterase inhibitors to treat Fragile X.

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Celebrating Teamwork: FRAXA’s 7th Year at Bruins 50/50 Event

February 7, 2024

Celebrating FRAXA’s 7th year at Bruins 50/50 Event: teamwork and community unite for Fragile X research.

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Shape Our Conversation: FRAXA Feedback Survey

February 1, 2024

Join FRAXA’s mission in shaping a brighter future for Fragile X research. Share your thoughts in our brief survey by February 15 and help us tailor our communication to your interests. Your insights are invaluable in our 30th year of progress.

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Callum Cup 2023 Group

Callum Cup’s Big Win: Millburn Charity Soccer Raises $26K for Fragile X Research

December 22, 2023

Discover the inspiring story of the Callum Cup in Millburn, NJ – a charity soccer match that raised over $26,000 for Fragile X research. Join us in celebrating community spirit and a commitment to a vital cause.

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Recruiting: Unveiling Probiotic Potential in Fragile X Syndrome Clinical Trial

December 20, 2023

First of its kind in Serbia, this clinical trial explores probiotic intervention as a potential treatment avenue for Fragile X syndrome.

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$100,000 Matching Challenge From The Robert & Ardis James Foundation

December 8, 2023

We are thrilled to announce FRAXA Research Foundation’s most significant and unique matching challenge of the year, thanks to the Robert & Ardis James Foundation. This challenge will help us bring top new talent to Fragile X research.

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