2026 Grants Archives

Stylized blue brain with an orange highlighted region representing the nucleus accumbens in Fragile X syndrome research

Bridging Naturalistic Behavior and Nucleus Accumbens in Fragile X Syndrome

April 9, 2026

How do sex and gene dosage interact to shape brain function and behavior in Fragile X syndrome? The team aims to uncover why symptoms differ between males and females.

Eric Wang and Alana O’Brien, researchers at the University of Florida working on an FMRP autoregulation gene therapy project for Fragile X syndrome.

Harnessing FMRP Autoregulation for Safer Gene Therapy in Fragile X

February 18, 2026

Fragile X syndrome gene therapy could be safer with an FMRP “safety dial” that self-regulates expression using natural FMR1 control elements.

Fragile X Unplugged: Establishing Mobile EEG as the Next Frontier

January 21, 2026

A $100,000 FRAXA grant to Cincinnati Children’s Hospital is simplifying and testing EEG technology for home use, improving clinical trial accessibility and efficiency.

FRAXA-DVI research team in the lab conducting preclinical Fragile X drug validation studies

FRAXA Drug Validation Initiative (FRAXA-DVI)

December 13, 2025

The FRAXA Drug Validation Initiative (FRAXA-DVI) provides streamlined, cost-effective preclinical testing to evaluate investigational and repurposed compounds for Fragile X syndrome.

Drs. Oswald Steward and Patricia Pirbhoy in their laboratory, studying RNA localization and gene activity in Fragile X syndrome using spatial transcriptomics.

Uncovering the Dynamics of FMR1 Using Spatial Transcriptomics for Fragile X

April 17, 2025

Scientists investigate how changes in RNA localization affect cognition and behavior in Fragile X, building knowledge toward more precise therapies.

Investigating the Role of the Insulin Degrading Enzyme (IDE) in Fragile X Syndrome

October 7, 2024

This study explores how disrupted insulin signaling affects metabolism and brain function in Fragile X, revealing new treatment targets for both body and mind.

Altered Physiology of Primary Visual Cortex in Fragile X Syndrome

September 19, 2024

This team believes inhibitory neurons expressing somatostatin are impaired in Fragile X. They will see if stimulating these neurons has therapeutic potential.

The Endocannabinoid System and Fragile X Syndrome

July 6, 2024

This project will examine how CBD and other drugs targeting the endocannabinoid system affect hyperexcitable Fragile X neurons to identify new treatment strategies.