Urgent Action Needed: Help Secure NIH Funding for Fragile X Research

March 13, 2025

NIH funding delays threaten Fragile X research, putting critical studies and future treatments at risk. Help us urge Congress and the NIH to act now.

Read More »

Renewed Hope: Navigating Towards a Cure for Fragile X Syndrome

April 16, 2024

Discover how Dr. Peter Todd’s latest Fragile X Syndrome research offers hope for advanced treatments and a possible cure, marking a new era in FXS therapy.

Read More »

ASOs and Fragile X: Addressing the Most Asked Questions

August 16, 2023

Explore the potential of ASOs in treating Fragile X syndrome & FXTAS. Dive into a comprehensive Q&A addressing key questions and breakthrough findings.

Read More »
2023 Fragile X Research Banbury Meeting (1)

Breakthrough Discoveries in Fragile X Research: Insights from Special Banbury Meeting on Curative Therapies

May 18, 2023

Explore the latest breakthroughs in Fragile X research unveiled at the recent Banbury Meeting. Discover novel strategies, from gene therapy to protein replacement, that bring hope for curative therapies.

Read More »

Contribution of Microglia to the Therapeutic Effects of Metformin and Adiponectin in Fragile X Syndrome

September 16, 2021

Why are some with Fragile X always hungry or overweight, yet rarely diabetic? This team is studying metabolism and testing treatments like metformin and diet.

Read More »

Towards Understanding the Role of FMRP in Human Brain Development Using Brain Organoids

December 8, 2020

Dr. Zhexing Wen and Dr. Peng Jin at Emory University School of Medicine join us in this seminar to present Understanding the Role of FMRP in Human Brain Development Using Brain Organoids.

Read More »
Elle Skala, Tracy King, Christie Rogers, Mary Beth Busby

National Institutes of Health Releases Fragile X Strategic Plan

November 15, 2019

FRAXA’s Elle Skala and supporter Mary Beth Busby visited NIH as the new Strategic Plan for Fragile X was released, shaping federal research priorities for years.

Read More »

How Promising is CRISPR for Fragile X?

August 14, 2018

Peter Todd, MD, PhD, Assistant Professor in the Department of Neurology in the University of Michigan Medical School, was awarded a FRAXA Research Grant for gene reactivation with the use of CRISPR. In this interview he tells us about CRISPR in Fragile X research, how realistic is it that it could turn the Fragile X gene back on, and if it can really cure Fragile X.

Read More »
David Nelson, PhD, FRAXA Investigator

Fragile X Mutant Mouse Models

September 10, 2016

With $375,000 in grants from FRAXA, Dr. David Nelson developed an array of advanced mouse models of Fragile X. These models are available at Jackson Labs (JAX).

Read More »
Dr. Haenfler and Dr. Todd

University of Michigan researcher Peter Todd, MD, PhD, Aims to Selectively Turn the Fragile X Gene Back on in Human Cells

June 13, 2016

University of Michigan scientists Peter Todd, MD, PhD, and postdoctoral fellow Jill Haenfler, Ph.D., are adapting CRISPR to reactivate the FMR1 gene to reverse Fragile X syndrome.

Read More »
David Nelson lab

Researcher David Nelson, PhD, Explores New Cell Strategies for Fragile X Syndrome, FXTAS and FXPOI

May 31, 2016

David Nelson co-discovered the FMR1 mutation which causes Fragile X syndrome and developed key mouse models, enabling global research aimed at finding treatments for the disorder.

Read More »
Kimberly Huber, Ph.D., FRAXA Investigator

NIH Awards $35 Million to Three Fragile X Research Teams

September 23, 2014

NIH is investing $35M in three Fragile X Research Centers. All teams have been funded by FRAXA and will now receive over $2M annually for five years.

Read More »

What Treatments Work for FXTAS?

March 25, 2014

FXTAS affects many in our Fragile X community. Research aims to uncover its cause and guide more effective treatments.

Read More »

Small Molecules To Target r(CGG) Expansions to Treat Fragile X Syndrome

January 24, 2014

FRAXA-funded scientists created small molecules that target the CGG repeat “off-switch” in Fragile X, aiming to restore the missing FMRP protein at its source.

Read More »

Efficient Screening for Pharmaceutical Amelioration of FXS Behavioral Deficits in Drosophila

January 30, 2012

Using a fruit-fly Fragile X model, researchers screened many drugs quickly to find those that improve behavior, speeding up potential treatment testing.

Read More »

Categories

FRAXA Funded Research

Current Research Grants (37)