dopamine Archives

Investigating the Role of the Insulin Degrading Enzyme (IDE) in Fragile X Syndrome

October 7, 2024

This study explores how disrupted insulin signaling affects metabolism and brain function in Fragile X, revealing new treatment targets for both body and mind.

Marvel Biosciences Partners with FRAXA to Test MB204 for Fragile X Syndrome

August 20, 2024

Marvel Biosciences and FRAXA Research Foundation are collaborating to test MB204, a promising new treatment for Fragile X which targets adenosine receptors.

Functional and Genomic Characterization of Interneurons in the Fmr1-KO Mouse Brain

September 22, 2022

The brain’s balance is maintained by two types of neurons: excitatory and inhibitory. This team has found fewer than normal inhibitory cells in Fragile X mice.

Aripiprazole (Abilify) in the Treatment of People with Fragile X: An Anecdotal Account

July 29, 2020

The aim of this article is to discuss the use of Abilify (generic name: aripiprazole) as a treatment for people with Fragile X syndrome (FXS). As an “off-label” prescription, Abilify targets behaviors such as irritability, aggression, self-injury and severe tantrums.

Considering Available Drugs for Fragile X: My Favorite Combination (So Far)

February 19, 2020

Which of the available drugs are best for managing fragile X syndrome? Most drugs have “off-target” effects which can have key advantages in some cases.

Treatment of Fragile X Syndrome via Dopamine Enhancers and Glutamate Inhibitors

June 2, 2013

In Fragile X mice, low dopamine signaling and excessive glutamate activity were targeted with dual therapy: dopamine enhancers plus glutamate inhibitors.

Reward Function in Fragile X Syndrome

September 2, 2012

Loss of FMRP disrupts dopamine-driven reward function—Fragile X mice show impaired cocaine sensitization and place preference, revealing new plasticity defects.

Social Deficits in Fragile X Syndrome: Do Gene-Gene Interactions Play a Role?

February 13, 2006

FRAXA’s $100K grant supported Drs. Jean Lauder and Sheryl Moy at UNC in exploring gene–gene interactions in Fragile X.

Investigating the Role of the Insulin Degrading Enzyme (IDE) in Fragile X Syndrome

Marvel Biosciences Partners with FRAXA to Test MB204 for Fragile X Syndrome

Functional and Genomic Characterization of Interneurons in the Fmr1-KO Mouse Brain

Aripiprazole (Abilify) in the Treatment of People with Fragile X: An Anecdotal Account

Considering Available Drugs for Fragile X: My Favorite Combination (So Far)

Treatment of Fragile X Syndrome via Dopamine Enhancers and Glutamate Inhibitors

Reward Function in Fragile X Syndrome

Social Deficits in Fragile X Syndrome: Do Gene-Gene Interactions Play a Role?

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