Quantitative Assessment of the Serotonin System in a Mouse Model of Fragile X Syndrome

FRAXA Research Foundation is proud to make a grant of $90,000 over two years to Clinton Canal, PhD.  Dr. Canal, previously a research assistant professor at Northeastern University, has just launched his own lab at Mercer University in Atlanta, GA. He and his graduate students are fully committed to Fragile X research.

$90,000 Grant
Clinton E. Canal, PhD
Principal Investigator
Mercer University
2017 FRAXA Research Grant
$90,000 over 2 Years

Many of the behavioral symptoms of Fragile X and other autism spectrum disorders suggest abnormalities of the brain’s serotonin system. The serotonin system is one of the primary regulators of mood and anxiety. However, despite obvious involvement of this system in Fragile X syndrome, no one has ever done a systematic investigation of serotonin receptors and how they might be involved in Fragile X.

This project seeks to redress this oversight by examining the function and the numbers of serotonin receptors of various subtypes (of which there are many!) in the brains of Fragile X knockout mice.

This is important, because many drugs in wide use today manipulate the serotonin system. We commonly use SSRI drugs like fluoxetine (Prozac) and sertraline (Zoloft) which block some serotonin receptors. Many people who have Fragile X are already being treated with these drugs. The results of this research will help us do a better job of helping people with Fragile X with existing, available medicines.

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FRAXA-funded researchers around the world are leading the way towards effective treatments and ultimately a cure.