Genome-wide Screen for FMR1 Reactivation in Human FXS Neural Cells

FRAXA Research Foundation 2017 Grants • 2018 Grants • Agency for Science, Technology and Research (A*STAR) • Genetic Rescue • Pouladi, Mahmoud • Research Grant Results • Utami, Kagistia October 2, 2017April 13, 2022NIH

Drs. Mahmoud Pouladi and Kagistia Utami at A*STAR in Singapore won a $67,500 research grant from FRAXA Research Foundation and that grant led to much greater governmental funding to expand this work. Their goal is to reactivate the gene which is silenced in people who have Fragile X syndrome.

Results Published: Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in FXS

Mahmoud A. Pouladi, PhD & Kagistia Utami, PhD of National University of Singapore and Agency for Science, Technology and Research (A*STAR)

$67,500 Grant

Kagistia Utami, PhD
FRAXA Fellow

Mahmoud A. Pouladi, PhD
Principal Investigator

National University of Singapore and Agency for Science, Technology and Research (A*STAR)

2017-18 FRAXA Research Grant
$67,500 over 18 Months

Fragile X syndrome (FXS) is caused by loss of a protein encoded on the X chromosome. Restoring the missing protein, known as FMRP, is expected to be the most effective therapeutic strategy for FXS, reversing the developmental delays and improving the clinical outcomes for patients with FXS.

With this Fragile X research grant the goal of Dr. Utami and Dr. Pouladi’s team at the Agency for Science, Technology and Research (A*STAR) is to use large-scale genetic approaches to identify novel factors that can reactivate the gene encoding FMRP in human FXS neurons.

Genome-wide Screen for FMR1 Reactivation in Human FXS Neural Cells

Global Leader in Fragile X Research

Global Leader in Fragile X Research