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Fragile X Research – FRAXA Research Foundation

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FRAXA Funded Research

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Pouladi, Mahmoud

Sigma-1 Receptor as a Therapeutic Target for Fragile X Syndrome

FRAXA Research Foundation November 22, 2022January 26, 2023

Dr. Pouladi’s team is exploring a treatment of Fragile X via the sigma-1 receptor. Drugs that boost activity at sigma receptors tend to calm down overactive neurons. They are also powerful anti-inflammatory drugs.

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Genome-wide Screen for FMR1 Reactivation in Human FXS Neural Cells

FRAXA Research Foundation October 2, 2020January 26, 2023
Mahmoud A. Pouladi, PhD & Kagistia Utami, PhD of National University of Singapore and Agency for Science, Technology and Research (A*STAR)

Drs. Mahmoud Pouladi and Kagistia Utami at the Agency for Science, Technology and Research (A*STAR) in Singapore were awarded a $67,500 research grant from FRAXA Research Foundation and that led to much greater governmental funding to expand this work. Their goal is to reactivate the gene which is silenced in people who have Fragile X syndrome.

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