Startle Modulation in Males with Fragile X Syndrome

February 27, 2001

FRAXA’s $42,720 grant helped Dr. Elisabeth Dykens uncover startle and PPI effects in Fragile X males. Results were published.

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Claudia Bagni, PhD, at University of Rome, FRAXA research grant

Molecular Interactions Between FMRP and Protein Translation Apparatus

February 27, 2001

FRAXA-funded Dr. Bagni uncovered how Fragile X disrupts protein synthesis control, advancing molecular understanding. Published results.

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Justin Fallon, PhD, Brown University, FRAXA research grant

Transcriptional Regulation of the Fragile X Gene (fmr1) in the Olfactory Bulb

January 9, 2001

With $35K from FRAXA, Dr. Justin Fallon’s team at Brown University mapped Fragile X granules and explored FMRP’s role in sensorimotor function.

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Menahem Segal, PhD, at Weizmann Institute, FRAXA research grant

Role of FMRP in Development and Maturation of Spine Synapses

February 27, 2000

With $160K from FRAXA, Drs. Segal and Braun studied Fragile X development in lab models to advance understanding. Results published.

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Mina Johnson-Glenberg, PhD, at University of Wisconsin, FRAXA research grant

Neural Network Model of Working Memory in Fragile X Syndrome

February 27, 2000

FRAXA-funded Dr. Johnson-Glenberg explored how Fragile X impacts memory and learning, offering insight into cognitive challenges.

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Melatonin Clinical Trial in Fragile X

February 27, 2000

FRAXA-funded Dr. Hagerman’s UC team explored melatonin’s effects in Fragile X, advancing understanding of treatment options. Results published.

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Paul Hagerman, PhD

FMR1 Gene Regulation

February 27, 2000

FRAXA-funded Dr. Paul Hagerman explored reactivating the FMR1 gene and measuring its expression to advance Fragile X treatment.

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Longitudinal Study of Children with Fragile X

February 27, 2000

With $30K from FRAXA, Dr. Don Bailey’s UNC team studied how children with Fragile X develop, focusing on learning, language, and behavior.

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Transport of the Fragile X Protein

February 27, 2000

With $123K from FRAXA, Dr. Alan Tartakoff at Case Western studied how FMRP moves in the brain and advanced antibody tools for Fragile X research.

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Jean-Louis Mandel, PhD, at Strasbourg, FRAXA research grant

Characterization of Two Novel FMRP Interacting Proteins

February 27, 2000

With $30K from FRAXA, Dr. Jean-Louis Mandel’s Strasbourg team studied two proteins to reveal how FMRP loss affects brain function in Fragile X.

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Synaptic Plasticity and Olfactory Learning in Fragile X

February 26, 2000

With $40K from FRAXA, Dr. John Larson’s UIC team used mice’s sense of smell to study memory, learning, and Fragile X–related brain function.

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Reactivation of the FMR1 Gene in Fragile X Patients Cells in Culture

January 14, 2000

FRAXA-funded Dr. Neri’s team in Italy tested strategies to reactivate the Fragile X gene, advancing curative research.

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Karel Svoboda, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Imaging of Neocortical Dendritic Spine Maturation in FMR1 Knockout Mice Using Two-Photon Laser Scanning Microscopy

June 16, 1999

With $30K from FRAXA, Dr. Karel Svoboda’s team at Cold Spring Harbor studied dendritic spine changes in Fragile X mouse brain circuits.

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W Ted Brown, MD, PhD

Improving Memory Reversal Testing and Treatment with AMPAkines in the Fragile X Knock-Out Mouse

June 27, 1998

FRAXA-funded Dr. W. Ted Brown studied learning deficits in Fragile X mice and tested Ampakine drugs for potential treatment.

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FRAXA Funded Research

Current Research Grants (42)