Characterization of Two Novel FMRP Interacting Proteins

With a $30,000 grant from FRAXA Research Foundation in 2000, Dr. Jean-Louis Mandel and his team at the University of Strasbourg studied the function of two proteins to better understand the affects of the absence of the FMR1 expression.

Jean-Louis Mandel
$30,000 Grant
Jean-Louis Mandel, PhD
Principal Investigator

Barbara Bardoni, PhD
FRAXA Postdoctoral Fellow (2000)

University of Strasbourg
2000 FRAXA Research Grant

Search for FMRP (Fragile X Protein) Cellular Function Through the Characterization of Two Novel FMRP Interacting Proteins

by Barbara Bardoni, 1/1/2000

We have searched for new proteins that interact with the Fragile X protein FMRP using a technique called the two-hybrid assay in yeast. After screening a mouse embryonic (E9.5-EE12.5) library, we found two novel proteins that we are currently characterizing: NUFIP1 (Nuclear FMRP Interacting Protein) and CYFIP (Cytoplasmic FMRP Interacting Protein). Understanding the functions of these new proteins is an essential step in the definition of the molecular and developmental mechanisms by which the absence of FMR1 expression causes Fragile X syndrome.

Jean-Louis Mandel, PhD, at Strasbourg, FRAXA research grant

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