University of North Carolina

Social Deficits in Fragile X Syndrome: Do Gene-Gene Interactions Play a Role?

FRAXA Research Foundation 2001-2005 Grants • 2006-2010 Grants • Completed Research Grants • Disease Mechanisms • Lauder, Jean • Moy, Sheryl • Treatment Targets • University of North Carolina February 13, 2006April 25, 2018Abilify, aripiprazole, autism, dopamine, glutamate, lithium, mGluR5, serotonin

With a $100,000 grant from FRAXA Research Foundation from 2005-2006, Drs. Jean Lauder and Sheryl Moy at the University of North Carolina looked for gene-gene interactions in Fragile X syndrome.

Dendritic Spine Formation and Fragile X

FRAXA Research Foundation 2001-2005 Grants • Brenman, Jay • Completed Research Grants • Disease Mechanisms • University of North Carolina February 27, 2003March 21, 2019fruit fly, MAP1b

With a $35,000 grant from FRAXA Research Foundation in 2003, Dr. Jay Brenman and his team at the University of North Carolina utilized the fruit fly (Drosophila) to model disease and examined the fly model of Fragile X in an effort to understand the basic mechanisms of disease.

Jay Brenman, PhD, at University of North Carolina, FRAXA research grant

Longitudinal Study of Children with Fragile X

FRAXA Research Foundation 1994-2000 Grants • Bailey, Don • Clinical • Completed Research Grants • University of North Carolina February 27, 2000January 14, 2019autism

With a $30,000 grant from FRAXA Research Foundation in 2000, Dr. Don Bailey and his team at the University of North Carolina studied the longitudinal development of children, with a focus on educational strategies and development of language. They have contributed greatly to our understanding of the course of Fragile X over a lifetime, as well as the frequency of autism and other behavioral complications in the Fragile X population.

Psychophysiological Measures of Arousal: Documentation of Treatment Effects & Impact of Disability

FRAXA Research Foundation 1994-2000 Grants • Bailey, Don • Completed Research Grants • University of North Carolina January 14, 1999January 14, 2019

With a $60,000 grant from FRAXA Research Foundation from 1998-2000, Dr. Don Bailey and his team at the University of North Carolina explored the role of arousal in individuals that are affected by Fragile X syndrome.