Organization Archives • Page 12 of 12 • FRAXA Research Foundation

Jean-Louis Mandel, PhD, at Strasbourg, FRAXA research grant

Characterization of Two Novel FMRP Interacting Proteins

February 27, 2000

With a $30,000 grant from FRAXA Research Foundation in 2000, Dr. Jean-Louis Mandel and his team at the University of Strasbourg studied the function of two proteins to better understand the affects of the absence of FMRP.

Synaptic Plasticity and Olfactory Learning in Fragile X

February 26, 2000

With a $40,000 grant from FRAXA Research Foundation in 2000, Dr. John Larson and his team at the University of Illinois Chicago used olfaction (sense of smell) in mice as a neuro-behavioral model system for human memory. They characterized olfactory sensitivity, learning, and memory in FMR1 knockout mice as compared to wild-type (normal control) mice.

Reactivation of the FMR1 Gene in Fragile X Patients Cells in Culture

January 14, 2000

With a $62,000 grant from FRAXA Research Foundation from 1999-2000, Dr. Giovanni Neri and his team at Universita Cattolica del S. Cuore explored possible strategies to turn the Fragile X gene back on.

Karel Svoboda, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Imaging of Neocortical Dendritic Spine Maturation in FMR1 Knockout Mice Using Two-Photon Laser Scanning Microscopy

June 16, 1999

With $30,000 in funding from FRAXA Research Foundation in 1999, Dr. Karel Svoboda and his team at the Cold Spring Harbor Laboratory explored the changing nature of dendritic spine motility by imaging neocortical circuits in Fragile X mice.

Psychophysiological Measures of Arousal: Documentation of Treatment Effects & Impact of Disability

January 14, 1999

With a $60,000 grant from FRAXA Research Foundation from 1998-2000, Dr. Don Bailey and his team at the University of North Carolina explored the role of arousal in individuals that are affected by Fragile X syndrome.

Improving Memory Reversal Testing and Treatment with AMPAkines in the Fragile X Knock-Out Mouse

June 27, 1998

A two year $62,000 FRAXA grant was been awarded to W. Ted Brown, MD, PhD from 1997-1998. The Principal Investigator at the Institute For Basic Research in New York aims to develop an improved test to show learning deficits in the FMR1 knock-out mouse model of Fragile X, and test experimental drugs (Ampakines) that may be effective in treating these deficits.