FRAXA-DVI Archives • Page 2 of 2 • FRAXA Research Foundation

Finding Fragile X Biomarkers – From Transcriptomics to Behavior in Patients

November 6, 2018

FRAXA funded a study using blood-based transcriptomics to find reliable Fragile X biomarkers. This unique approach links molecular data to behavior for future trials.

Meng Li, PhD, Xinyu Zhao, PhD, and Anita Bhattacharyya, PhD

FRAXA Research Grants Drive Big Investments in Fragile X

March 28, 2018

FRAXA is working with hundreds of university labs and more than 30 pharmaceutical companies around the world. Dr. Michael Tranfaglia spends a lot of his time advising and collaborating with industry partners.

Repurposing Study II: Evaluating Combinations of Drugs to Treat Fragile X

February 8, 2018

FRAXA partnered with Healx to use AI to find approved drugs and drug combos that could treat Fragile X. Top candidates are now being tested in Fragile X models.

Healx team David, Dan, Narissa - FRAXA (1)

Drug Repurposing Study Results Accelerate Progress Towards Fragile X Treatments

October 29, 2017

Drug repurposing leverages the detailed information available on approved drugs and reduces the time and money needed to deliver safe “new” treatments, with greater success rates and quicker impact.

Repurposing Available Drugs to Treat Fragile X Syndrome – FRAXA Initiatives

February 10, 2017

FRAXA is identifying existing, approved drugs that could be repurposed for Fragile X, allowing potential treatments to move faster and at lower risk than starting from scratch.

Identifying Biomarkers for Fragile X Syndrome – A Study in Argentina

August 1, 2016

FRAXA funds biomarker research to develop objective, biological measures of Fragile X, helping predict treatment response, guide trials, and move therapies toward FDA approval.

New compound from Anavex Improves Learning and Behavior in Fragile X Mice

June 6, 2016

The investigational drug Anavex 2-73 was able to improve intellectual, learning and hyperactivity measures in a mouse model of Fragile X syndrome. This is a sigma-1 receptor agonist.

Bryostatin Restores Learning and Memory in Adult Fragile X Mice

March 11, 2015

A marine critter found off the California coast — Bugula neritina — is the only source of Bryostatin. Bryostatin-1 restores spatial learning and memory in adult Fragile X mice.