baclofen Archives • Fragile X Research - FRAXA Research Foundation

Social Behavior as an Outcome Measure for Fragile X Clinical Trials

FRAXA Research Foundation 2012 Grants, 2013 Grants, Clinical, Completed Research Grant, Drug Repurposing, Erasmus University Rotterdam, Grant, Rob Willemsen, PhD, Treatment Targets September 13, 2013April 25, 2018baclofen, ERK, mGluR5, minocycline

One of the features of the fragile X mouse model which is relevant to the human fragile X syndrome (and autism) is social behavior. Several tests show consistent social behavioral abnormalities in the fragile X mouse model. With a $140,000 grant from FRAXA Research Foundation in 2012-2013, Dr. Willemsen at Erasmus University used social behavior tests to measure the effectiveness of several drug strategies.

Genome-wide Epigenetic Markers in Fragile X

FRAXA Research Foundation 2001-2005 Grants, 2006-2010 Grants, Completed Research Grant, Cornell University, Disease Mechanisms, Ji-eun Oh, PhD, Miklos Toth, PhD, Treatment Targets February 5, 2009April 25, 2018baclofen, epigenetics

With $155,000 in grants from FRAXA Research Foundation over several years, Dr. Miklos Toth of Cornell University discovered increased startle response in fragile X mice and that baclofen can correct this phenotype. They also studied epigenetics (ie factors other than the gene itself) which can determine symptom severity in fragile X.