Targeting Serotonin 1A Receptors in Fmr1 Knockout Mice

Boosting serotonin 1A receptors may reduce excess brain activity in Fragile X. This study will test serotonin-1A–targeting compounds in mice to guide future treatments.

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Meng Li, PhD, Xinyu Zhao, PhD, and Anita Bhattacharyya, PhD

FRAXA Research Grants Drive Big Investments in Fragile X

FRAXA is working with hundreds of university labs and more than 30 pharmaceutical companies around the world. Dr. Michael Tranfaglia spends a lot of his time advising and collaborating with industry partners.

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Quantitative Assessment of the Serotonin System in a Mouse Model of Fragile X Syndrome

FRAXA funded Dr. Canal to investigate how different serotonin receptors function in Fragile X, to guide smarter use of serotonin-targeting treatments.

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Clinton Canal, PhD

Targeting Serotonin Receptors to Treat Behavioral and Psychological Symptoms

Dr. Clinton Canal targets serotonin receptors to correct brain signaling in Fragile X, guiding drug discovery and repurposing of therapies for anxiety, seizures, and behavior.

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FRAXA Funded Research

Current Research Grants (37)