University of Michigan Archives • FRAXA Research Foundation

CRISPR Reactivation of the Fragile X Gene

December 6, 2017

Using CRISPR to reactivate FMRP, “We are trying to target the first event that goes wrong in Fragile X syndrome”, says FRAXA Investigator, Dr. Peter Todd.

Targeted Transcriptional Reactivation of FMR1 in Fragile X Syndrome Stem Cells

September 23, 2017

FRAXA funded Dr. Peter Todd to use CRISPR to reactivate FMR1. Published results confirmed restored gene expression, a big step toward disease-modifying therapy.

University of Michigan researcher Peter Todd, MD, PhD, Aims to Selectively Turn the Fragile X Gene Back on in Human Cells

June 13, 2016

University of Michigan scientists Peter Todd, MD, PhD, and postdoctoral fellow Jill Haenfler, Ph.D., are adapting CRISPR to reactivate the FMR1 gene to reverse Fragile X syndrome.

CRISPR Reactivation of the Fragile X Gene

Targeted Transcriptional Reactivation of FMR1 in Fragile X Syndrome Stem Cells

University of Michigan researcher Peter Todd, MD, PhD, Aims to Selectively Turn the Fragile X Gene Back on in Human Cells

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