A Tat-Conjugate Approach to Treat Fragile X Syndrome

July 9, 2025

Turner Lab’s innovative approach to treating Fragile X uses a Tat-linked, truncated FMRP protein designed to restore brain function by replacing the missing protein.

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Validating Novel Inhibitors of ERK Signalling to Treat Fragile X Syndrome

February 13, 2023

This team is testing ERK inhibitors — drugs that may calm overactive brain signaling in Fragile X. Early results in mice show strong benefits with minimal side effects.

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Ray Turner, PhD and Xiaoqin Zhan, PhD

Reintroducing FMRP via Tat to Reduce Symptoms of Fragile X Syndrome

March 26, 2019

A FRAXA-funded team found that a shortened FMRP protein, delivered with a Tat “carrier,” restores brain signaling and improves behavior in Fragile X mice.

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FRAXA Funded Research

Current Research Grants (38)