Organization Archives • Page 11 of 12 • FRAXA Research Foundation

Catherine Choi, Drexel University, FRAXA research grant

Pharmacologic Interventions in the Fmr1 KO Mouse

February 13, 2006

With $48.6K from FRAXA, Dr. Catherine Choi at Drexel studied Fragile X knockout mice to identify potential treatment targets.

Stephanie Ceman, PhD, at University of Illinois at Urbana-Champaign, FRAXA research grant

FMR Expression in Zebra Finch

February 13, 2006

With $18.5K from FRAXA, Dr. Stephanie Ceman at Illinois used zebra finches to study how Fragile X affects speech and vocal learning. Results published.

Robert Bauchwitz, MD, PhD, at Columbia University, FRAXA research grant

Transgenic Mouse Models of Fragile X Syndrome

February 13, 2006

With $736K from FRAXA, Dr. Bauchwitz built 15 Fragile X mouse models at Columbia to test and publish results on new treatments.

Composition and Dynamics of FMRP-Containing RNP Complexes

September 20, 2005

A $30K FRAXA grant helped Dr. Barbara Bardoni at INSERM, France, explore the biochemistry and function of the Fragile X protein.

Thomas Tuschl, PhD, at Rockefeller University, FRAXA research grant

Role of MicroRNAs in Fragile X Syndrome

February 22, 2005

A $70K FRAXA grant helped Drs. Thomas Tuschl and Neil Renwick study FMRP–miRNA links to identify better treatment targets for Fragile X.

Karel Svoboda, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Intracortical Circuitry in the Barrel Cortex of FMR1-KO Mice

February 22, 2005

With $40K from FRAXA, Dr. Karel Svoboda at Cold Spring Harbor imaged brain circuits in Fragile X mice to study abnormal dendritic spines.

Vladimir Gelfand, PhD, at Northwestern University, FRAXA research grant

Transport, Anchoring and Translation of FMRP-Associated mRNAs

February 15, 2005

FRAXA’s $40K grant supported Dr. Vladimir Gelfand’s Northwestern team in exploring links between mGluR, mRNA, and FMRP.

Reactivating the FMR1 Gene

February 27, 2004

With $171.6K from FRAXA, Dr. Andre Hoogeveen’s Erasmus team developed methods to reactivate the Fragile X gene, advancing curative research.

Holly Cline, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

FMRP Function in the Xenopus Visual System

February 27, 2004

With $75K from FRAXA, Dr. Holly Cline at Cold Spring Harbor studied Fragile X proteins and mRNA regulation in tadpoles.

Fragile X Syndrome and RNAi

February 27, 2004

With $75K from FRAXA, Dr. Richard Carthew at Northwestern studied how RNA interference (RNAi) and FMRP interact in Fragile X.

Clive Svendsen, PhD, at University of Wisconsin, FRAXA research grant

Generating Human Neurons Carrying the Fragile X Mutation

February 26, 2004

FRAXA’s $50K grant supported Dr. Clive Svendsen at Wisconsin in growing Fragile X stem cells to better understand gene characteristics.

Edouard Khandijian, PhD, at Laval University, FRAXA research grant

Xenopus (Frog) Model System of Fragile X and Related Proteins

February 26, 2004

With $50K from FRAXA, Dr. Edouard Khandjian at Laval University studied FMR1 and related genes FXR1 and FXR2 in frog models of Fragile X.

Fruit Fly Helps Reveal the Secrets of Fragile X

February 26, 2004

FRAXA’s $50K grant supported Dr. Bassem Hassan’s Flanders team in using fruit flies to model Fragile X and guide future therapy studies.

Kenneth J. Mack, MD, PhD, at Mayo Clinic, FRAXA research grant

Role of Experience in Regulating Levels of the Fragile X Protein

January 1, 2004

With $49K from FRAXA, Drs. Mack and Todd studied how brain stimulation changes FMRP levels, deepening Fragile X research insight.

David Bloom, PhD, at University of Florida, FRAXA research grant

FMR1 Gene Delivery Using Herpes Simplex Virus Vectors

March 1, 2003

With $89K from FRAXA, Dr. David Bloom’s team advanced Fragile X gene therapy by transferring the fmr1 gene into mouse brains via viral vectors.

Jay Brenman, PhD, at University of North Carolina, FRAXA research grant

Dendritic Spine Formation and Fragile X

February 27, 2003

With $35K from FRAXA, Dr. Jay Brenman at UNC used fruit fly models to study Fragile X and uncover key disease mechanisms.

Jerry Yin, PhD, at University of Wisconsin, FRAXA research grant

DFXR and Synaptic Tagging in Drosophila (Fruit Flies)

February 27, 2003

FRAXA’s $135K grant supported Dr. Jerry Yin’s Fragile X fruit fly studies on memory formation at Wisconsin’s Waisman Center.

Haruhiko Siomi, PhD, at Tokushima University, FRAXA research grant

Understanding the Function of Fragile X Protein in Drosophila

February 26, 2003

FRAXA-funded Tokushima researchers mapped the Drosophila FMR1 gene and its pathways, revealing how Fragile X disrupts cell function.

Assam El-Osta, PhD, at Peter MacCallum Cancer Institute, Australia, FRAXA research grant

FMR1 Repression and the Signals to Chromatin

February 26, 2003

With $70K from FRAXA, Dr. Assam El-Osta’s team at Peter MacCallum Cancer Institute studied FMR1 silencing and histone regulation in Fragile X.

Molecular Basis of Increased Seizure Severity in the Fragile X Knockout Mouse

February 26, 2003

FRAXA’s $50K grant supported Dr. Carl Dobkin’s team in uncovering why Fragile X mice show increased seizure activity. Findings published.

Isolating and Characterizing the mRNAs That Bind FMRP

January 14, 2003

With $60K from FRAXA, Dr. Denman’s team investigated how the Fragile X protein FMRP functions in the brain.

Linda Crnic, PhD, at University of Colorado, FRAXA research grant

Treatment of a Mouse Model of Fragile X Syndrome with MPEP

January 1, 2003

A $49K FRAXA grant helped Dr. Linda Crnic’s Colorado team study chronic MPEP use to ease Fragile X symptoms while preserving cognition.

Structure of FMRP

February 27, 2002

With $68K from FRAXA, Dr. Lynne Regan at Yale studied how protein shapes influence Fragile X function. Results were published.

Prospects For Gene Therapy in the Fragile X

February 27, 2002

FRAXA-funded Dr. Rattazzi explored gene therapy to transfer the FMR1 gene into the brain of Fragile X mice, publishing key results.

Pharmacologic Interventions in the Fmr1 KO Mouse

FMR Expression in Zebra Finch

Transgenic Mouse Models of Fragile X Syndrome

Composition and Dynamics of FMRP-Containing RNP Complexes

Role of MicroRNAs in Fragile X Syndrome

Intracortical Circuitry in the Barrel Cortex of FMR1-KO Mice

Transport, Anchoring and Translation of FMRP-Associated mRNAs

Reactivating the FMR1 Gene

FMRP Function in the Xenopus Visual System

Fragile X Syndrome and RNAi

Generating Human Neurons Carrying the Fragile X Mutation

Xenopus (Frog) Model System of Fragile X and Related Proteins

Fruit Fly Helps Reveal the Secrets of Fragile X

Role of Experience in Regulating Levels of the Fragile X Protein

FMR1 Gene Delivery Using Herpes Simplex Virus Vectors

Dendritic Spine Formation and Fragile X

DFXR and Synaptic Tagging in Drosophila (Fruit Flies)

Understanding the Function of Fragile X Protein in Drosophila

FMR1 Repression and the Signals to Chromatin

Molecular Basis of Increased Seizure Severity in the Fragile X Knockout Mouse

Isolating and Characterizing the mRNAs That Bind FMRP

Treatment of a Mouse Model of Fragile X Syndrome with MPEP

Structure of FMRP

Prospects For Gene Therapy in the Fragile X

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