sound

Why study auditory systems in Fragile X syndrome? The brain’s system for processing sounds is much better known and easier to study than learning and memory processing. Researchers are finding that interventions and treatments which normalize auditory systems (in Fragile X animal models) also correct cognition.

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Electrophysiological, Biochemical and Immunohistochemical Characterization of Kv3.1 in Auditory Brainstem Nuclei in the Fragile X Knockout Mouse

FRAXA Research Foundation 2006-2010 Grants • Kaczmarek, Leonard • Treatment Targets • Yale University , , , , ,
Electrophysiological, Biochemical and Immunohistochemical Characterization of Kv3.1 in Auditory Brainstem Nuclei in the Fragile X Knockout Mouse

With $80,000 in funding from FRAXA over several years, the Yale University team of Leonard Kaczmarek, PhD showed that loss of FMRP leads to an increased Kv3.1 potassium currents. This change impairs timing of action potentials in auditory neurons (and likely others throughout the brain).

Leonard Kaczmarek, PhDRead more

Baclofen: GABA(B) Receptor Supersensitivity and Normalization of Behavioral Abnormalities by Various GABA(B) Agonists Including Baclofen in FMRP Deficient Mice

FRAXA Research Foundation 2001-2005 Grants • 2006-2010 Grants • Completed Research Grants • Cornell University • Disease Mechanisms • Oh, Ji-eun • Toth, Miklos • Treatment Targets , , , , ,
Baclofen: GABA(B) Receptor Supersensitivity and Normalization of Behavioral Abnormalities by Various GABA(B) Agonists Including Baclofen in FMRP Deficient Mice

With $110,000 in grants from FRAXA Research Foundation over several years, Dr. Miklos Toth from Cornell University discovered increased startle response in Fragile X mice and that baclofen can correct this phenotype.

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Genetic and Behavioral Analyses of the dFMR1 Pathway in Drosophila Peripheral Nervous System

FRAXA Research Foundation 2001-2005 Grants • 2006-2010 Grants • Completed Research Grants • Disease Mechanisms • Gao, Fen-Biao • University of California at San Francisco , ,
Genetic and Behavioral Analyses of the dFMR1 Pathway in Drosophila Peripheral Nervous System

With a $160,000 grant from FRAXA Research Foundation from 2004-2006, Dr. Fen-Biao Gao and his team at the University of California studied the relationship between mRNA and FMRP.

Fen-Biao Gao, PhD, at University of California at San Fransico, FRAXA research awardRead more

Molecular Basis of Increased Seizure Severity in the Fragile X Knockout Mouse

FRAXA Research Foundation 2001-2005 Grants • Disease Mechanisms • Dobkin, Carl • El Idrissi, Abdeslem • New York State Institute for Basic Research • Research Grant Results , , ,

With a $50,000 grant from FRAXA Research Foundation from 2002-2003, Dr. Carl Dobkin and his team at the New York Institute for Basic Research studied the causes for heightened seizure activity in Fragile X mice. Results published.

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Treatment of a Mouse Model of Fragile X Syndrome with MPEP

FRAXA Research Foundation 2001-2005 Grants • Completed Research Grants • Crnic, Linda • Treatment Targets • University of Colorado , , , ,
Treatment of a Mouse Model of Fragile X Syndrome with MPEP

With a $49,000 grant from FRAXA Research Foundation in 2003, Dr. Linda Crnic at the University of Colorado continued studies of MPEP in Fragile X mice, exploring whether chronic use improves symptoms of Fragile X syndrome without impairing cognitive function.

Linda Crnic, PhD, at University of Colorado, FRAXA research grantRead more

Melatonin Clinical Trial in Fragile X

FRAXA Research Foundation 1994-2000 Grants • Disease Mechanisms • Hagerman, Randi • Has Results • Research Grant Results • Treatment Targets • University of California at Davis , , , , ,
Melatonin Clinical Trial in Fragile X

With a $60,000 grant from FRAXA Research Foundation from 1998-1999, Dr. Randi Hagerman and her team at the University of California studied the effects of different compounds on individuals with Fragile X syndrome, focusing specifically on melatonin. Results published.

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