Human Neurons

Retinoic Acid Signaling is Blocked by Fragile X Mutation

This FRAXA-funded team at Stanford University found that the Fragile X mutation impairs homeostatic plasticity in human neurons, by blocking synaptic retinoic acid signaling.

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Synaptic Characterization of Human Fragile X Neurons

Stanford scientists used human stem-cell–derived neurons to show that retinoic acid signaling is blocked by Fragile X, revealing a new pathway to target for treatment.

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FRAXA Funded Research

Current Research Grants (38)