Role of MicroRNAs in Fragile X Syndrome

Role of MicroRNAs in Fragile X Syndrome

With a $70,000 grant from FRAXA Research Foundation from 2004-2005, Drs. Thomas Tuschl and Neil Renwick and their team at Rockefeller University researched how FMRP interacts with miRNA in order to determine more effective treatment targets for Fragile X syndrome.

Read more

DFXR and Synaptic Tagging in Drosophila (Fruit Flies)

DFXR and Synaptic Tagging in Drosophila (Fruit Flies)

With a $135,000 grant from FRAXA Research Foundation from 2001-2003, Dr. Jerry Yin and his team at the University of Wisconsin researched memory formation in Fragile X fruit flies. Dr. Yin started his Fragile X studies at Cold Spring Harbor Laboratory before moving to the Waisman Center.

Read more

Understanding the Function of Fragile X Protein in Drosophila

Understanding the Function of Fragile X Protein in Drosophila

With a $105,000 grant from FRAXA Research Foundation from 2000-2003, Drs. Haruhiko Siomi and Mikko Siomi at Tokushima University researched approaches to characterize the Drosophila homolog of FMR1 and its associated molecules, and to identify molecular pathways that are involved in the cellular processes which are affected by the loss-of-function of Drosophila FMR1.

Read more

Identification of Specific RNA Targets of FMRP

Identification of Specific RNA Targets of FMRP

With a $70,000 grant from FRAXA Research Foundation from 1999-2001, Dr. Robert Darnell and his team at Rockefeller University made significant contributions towards understanding how FMRP functions and how the brain is affected without it. Results published.

Read more

Molecular Interactions Between FMRP and Protein Translation Apparatus

Molecular Interactions Between FMRP and Protein Translation Apparatus

With a $65,000 grant from FRAXA Research Foundation from 2000-2001, Dr. Claudia Bagni focused on understanding the specific molecular interactions which regulate protein synthesis, and how they are altered in Fragile X.  Dr. Bagni has moved from the University of Rome to VIB in Leuven, Belgium. Results published.

Read more

Transcriptional Regulation of the Fragile X Gene (fmr1) in the Olfactory Bulb

Transcriptional Regulation of the Fragile X Gene (fmr1) in the Olfactory Bulb

With a $35,000 in grant from FRAXA Research Foundation, Dr. Justin Fallon and his team at Brown University studied systematic mapping of Fragile X granules in developing mouse brains, revealing a potential role for presynaptic FMRP in sensorimotor functions.

Read more

Transport of the Fragile X Protein

Transport of the Fragile X Protein

With a $123,000 grant from FRAXA Research Foundation from 1998-2000, Dr. Alan Tartakoff at the Case Western Reserve University studied how proteins communicate with the brain, how and when FMRP travels in the brain, and how to introduce more antibodies to Fragile X research.

Read more