MRI Archives

fNIRS to Measure Treatment Response in Young Children with Fragile X

February 13, 2024

The team tested functional near-infrared spectroscopy (fNIRS). fNIRS uses light sources and sensors on the scalp to build a heat map of the brain in action.

Lovamix: Clinical Trial of Combined Treatment of Minocycline and Lovastatin in Fragile X Syndrome

February 3, 2022

FRAXA funded the LovaMiX trial of lovastatin + minocycline for Fragile X. 2022 results show safety and support continued study of this dual-target treatment approach.

Overcoming the Placebo Effect in Fragile X Clinical Trials

October 28, 2020

In a placebo-controlled clinical trial, some participants are given an experimental medication, while others are given a placebo. A strong placebo effect can obscure results.

Non-Invasive Imaging as a Biomarker for Fragile X Clinical Trials

September 6, 2018

FRAXA funded MRI research to track brain connectivity changes in Fragile X. This could yield objective biomarkers for testing treatments in mice and humans.

Double Down: Fragile X Clinical Trial Combines Two Available Drugs

May 16, 2016

FRAXA funded a trial combining lovastatin and minocycline to test whether targeting multiple pathways can improve brain activity and behavior in Fragile X.

Fragile X Programs at UMASS – University of MA, Worcester

March 11, 2015

Fragile X Syndrome Behavioral Health Clinic The Center for Autism and Neurodevelopmental Disorders (CANDO) is opening a specialty clinic for individuals with Fragile X Syndrome (under the direction of Dr. Jean Frazier) to evaluate and provide treatment for behavioral challenges.