Justin Cowan, PhD — University of Chile

Justin Cowan, PhD — University of Chile

Treatment of Fragile X Syndrome via Dopamine Enhancers and Glutamate Inhibitors with Patricia Cogram, PhD   FRAXA Awards: $50,000 in 2011 $50,000 in 2010       Project Description by Justin Cowan, 4/1/2010 Dopamine Enhancers and Glutamate Inhibitors This project aims to follow up our and others observations that the dopamine receptor is under expressed in the Fragile X syndrome and thus determine the effectiveness of targeted pharmacological treatments in Fragile X syndrome. We hope to increase our understanding of the mechanism of under expression of dopamine in fmr1 knockout mice and to test whether drugs that activate dopamine release and glutamate inhibition can alleviate the clinical symptoms of Fragile X syndrome. For the purpose of this project, we are investigating two compounds, Safinamide and Kuvan (BH4). We are using human cortical cells fmr1-/- to analyze the direct effects of these compounds on the neuronal phenotype and also to help

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Reward Function in Fragile X Syndrome

Reward Function in Fragile X Syndrome

With a $82,500 grant from FRAXA Research Foundation in 2011-2012, Dr. Christopher Cowan and Dr. Laura Smith explored the role of specific signaling pathways in drug-related behavioral deficits, including determining the role, if any, of known impairments in the Fragile X brain.

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Social Deficits in Fragile X Syndrome: Do Gene-Gene Interactions Play a Role?

Social Deficits in Fragile X Syndrome: Do Gene-Gene Interactions Play a Role?

With a $100,000 grant from FRAXA Research Foundation from 2005-2006, Drs. Jean Lauder and Sheryl Moy at the University of North Carolina looked for gene-gene interactions in Fragile X syndrome.

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