Boosting cAMP signaling restores memory and fixes brain-signaling defects in Fragile X models, suggesting diabetes drugs like metformin may help.
FRAXA’s $380K grant supported Drs. McBride, Jongens, and Choi in validating Fragile X treatments in mice to prepare for trials. Findings published.
With $48.6K from FRAXA, Dr. Catherine Choi at Drexel studied Fragile X knockout mice to identify potential treatment targets.
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Select ResearcherAbolghasemi, Armita (1)Albeck, David (1)Alger, Bradley (1)Allada, Ravi (1)Allen, Nicola (1)Annear, Dale (2)Bacigalupo, Juan (1)Bagni, Claudia (3)Bailey, Don (2)Banerjee, Probal (1)Banke, Tue (2)Bardoni, Barbara (6)Barnes, Stephanie (3)Bassell, Gary (3)Bauchwitz, Robert (1)Bear, Mark (16)Beasley, Lindsay (1)Bergdolt, Lara (1)Berry-Kravis, Elizabeth (17)Bettio, Luis (1)Bhakar, Asha (1)Bhattacharya, Aditi (2)Bhattacharyya, Anita (5)Bilousova, Tina (1)Binder, Devin (4)Bloom, David (1)Borreca, Antonella (4)Bosch, Miquel (1)Boussadia, Zaira (2)Brager, Darrin (1)Braun, Katarina (1)Brenman, Jay (1)Brennan, Francis (1)Briault, Sylvain (4)Broadie, Kendal (1)Brown, W Ted (1)Budylin, Tatyana (1)Caku, Artuela (2)Canal, Clinton E. (4)Carthew, Richard (1)Carullo, Paulina (2)Castren, Maija (1)Cea-Del Rio, Christian (1)Ceman, Stephanie (1)Chattarji, Sumantra (3)Chen, Chloe (2)Cheng, Ning (1)Choi, Catherine (3)Christie, Brian (2)Ciranna, Lucia (1)Cline, Holly (1)Cogram, Patricia (8)Contractor, Anis (2)Corbin, Francois (3)Corbin, Joshua (1)Coulson, Rochelle (2)Cowan, Christopher (1)Cowan, Justin (1)Cox, Charles (1)Crnic, Linda (1)Croom, Katilynne (1)Darnell, Jennifer (1)Darnell, Robert (1)Davidovic, Laetitia (1)Davidson, Beverly (1)de la Torre, Rafael (2)De Stefano, Lisa (1)de Vrij, Femke (1)Deacon, Robert (2)Dempsey, Graham (1)Deng, James (1)Deng, Pan-Yue (1)Denman, Robert (2)Di Marino, Daniele (1)Dierssen, Mara (2)Dijck, Anke Van (2)Dionne, Olivier (1)Disney, Matthew (1)Dobkin, Carl (1)Dockendorff, Thomas (1)Doering, Laurie (1)Dumontier, Dimitri (1)Dunaevsky, Anna (1)Dykens, Elisabeth (1)El Idrissi, Abdeslem (1)El-Osta, Assam (1)Erickson, Craig (13)Ethell, Iryna (6)Fallon, Justin (2)Feng, Jia (1)Feng, Yue (1)Fink, James (1)Finucane, Brenda (1)Francesconi, Anna (1)Frick, Andreas (2)Galera-López, Lorena (1)Gan, Wen-Biao (2)Gantois, Ilse (2)Gao, Fen-Biao (1)Gao, Pan (1)Garkun, Yury (1)Gatto, Cheryl (1)Gelfand, Vladimir (1)Geoffroy, Andrea (1)Germain, Noelle (1)Giangrande, Angela (1)Gibson, Jay (2)Goncalves, Tiago (1)Greenough, William (1)Grokoski, Kamila Castro (1)Gross, Christina (2)Guiotto, Annamaria (1)Gurney, Mark (2)Gutierrez, Alejandra (1)Ha, Seong Eon (1)Haenfler, Jill (1)Hagerman, Paul (1)Hagerman, Randi (2)Haggarty, Stephen (1)Hassan, Bassem (1)He, Qionger (2)Heaney, Chelcie (1)Hessl, David (1)Higashimori, Haruki (1)Hogan, Carolyn Ann (1)Holley, Andrew (1)Hoogeveen, Andre (1)Huber, Kimberly (8)Huganier, Richard (1)Huntsman, Molly (2)Ingolia, Nicholas (1)Jaffrey, Samie (3)Jiang, Yong-Hui (1)Jin, Peng (5)Johnson-Glenberg, Mina (1)Johnston, Daniel (2)Jonak, Carrie (1)Jonas, Elizabeth (3)Jongens, Tom (4)Jope, Richard (1)Joyce, Karen (1)Kaczmarek, Leonard (7)Kandel, Eric (1)Kanellpoulos, Alexandros (1)Kang, Seo-Jun (1)Kang, Yunhee (2)Kaufmann, Walter (1)Khandjian, Edouard (1)Kim, Hwan (1)Kim, J. 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(4)Smith, Elizabeth (1)Smith, Laura N. (1)Smith, Stephen E.P. (1)Soderling, Scott (1)Sonenberg, Nahum (6)Spolaor, Fabiola (1)Stackhouse, Tracy (1)Stamenkovic, Vera (1)Stanfield, Andrew (1)Steward, Oswald (2)Svendsen, Clive (1)Svoboda, Karel (2)Tang, Weiping (1)Tartaglia, Nicole (1)Tartakoff, Alan (1)Tejada-Simons, MariVi (1)Tempio, Alessandra (1)Thacker, Jonathan (1)Tiedge, Henri (1)Todd, Peter (9)Tonegawa, Susumu (1)Toth, Miklos (2)Tremblay, Marie-Eve (1)Tsai, Nien-Pei (1)Tsai, Yuan-Chen (1)Turner, Raymond (3)Tuschl, Thomas (1)Usdin, Karen (1)Utami, Kagistia (1)van der Lei, Mathijs (3)Vanderklish, Peter (8)Wang, Gordon (2)Wang, Hongbing (1)Warren, Stephen (2)Watanabe, Momoko (1)Weiler, Ivan Jeanne (1)Weisz, Eliana D. (1)Wen, Zhexing (4)Wernig, Marius (1)Westmark, Cara (5)Whitehead, Kathryn (1)Wilhelm, Michael (1)Wilkinson, Carol (5)Willemsen, Rob (1)Williams, Leena E. 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