Fragile X Syndrome Protein Linked to Breast Cancer Progression

Claudia Bagni (VIB/KU Leuven, Belgium, and the University of Rome, Italy) and colleagues have identified the way Fragile X Mental Retardation Protein or FMRP contributes to the progression of breast cancer. The researchers demonstrated that FMRP acts as a master switch controlling the levels of several proteins involved in different stages of aggressive breast cancer, including the invasion of cancer cells into blood vessels and the spread of these cancer cells to other tissues forming metastasis.

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Molecular Interactions Between FMRP and Protein Translation Apparatus

Molecular Interactions Between FMRP and Protein Translation Apparatus

With a $65,000 grant from FRAXA Research Foundation from 2000-2001, Dr. Claudia Bagni focused on understanding the specific molecular interactions which regulate protein synthesis, and how they are altered in Fragile X.  Dr. Bagni has moved from the University of Rome to VIB in Leuven, Belgium. Results published.

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