Karen O'Malley

Defining Subcellular Specificity of Metabotropic Glutamate Receptor (mGluR5) Antagonists

This study showed that selectively targeting mGluR5 receptors in specific neuronal compartments can correct distinct Fragile X synaptic defects, improving precision therapy.

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Translation-Independent Functions of FMRP in Excitability, Synaptic Transmission and Plasticity

Study pinpointed presynaptic calcium dysfunction as the driver of STP defects in Fragile X, and BK channel activation restored normal synaptic signaling.

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FRAXA Funded Research

Current Research Grants (38)