Synaptic Characterization of Human Fragile X Neurons

Synaptic Characterization of Human Fragile X Neurons

With a $90,000 grant from FRAXA Research Foundation over 2013-14, Dr. Marius Wernig and Dr. Samuele Marro at Stanford analyzed homeostatic plasticity and regulation of synaptic strength by retinoic acid. If the results are encouraging, they will move forward with testing whether available RA antagonists can alleviate observed abnormalities in these cells.

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Composition and Localization of Dendritic mRNAs in Fragile X Syndrome

With a $80,000 grant from FRAXA Research Foundation over 2 years, Drs. Smith and Wang are investigating which proteins, as well as the mRNA's that code those proteins, are dysregulated in Fragile X. They have developed a elegant system to visualize the proteins and mRNA's and determine where they are spacially in the neuron. This will help to better understand the root causes of Fragile X syndrome and to design targeted treatments. $80,000 Grant Stephen Smith, PhD Principal Investigator Stanford University 2008-2009 FRAXA Research Grant $80,000 over 2 Years A Quantitative Study by Array Tomographic Florescent In Situ Hybridization by Gordon Wang, 8/1/2008 Fragile X syndrome is caused by the malfunction of a fundamental cellular process, the ability of cells to regulate spatially distinct pools of messenger RNA (mRNA). One of the cell types most affected is the neuron. This highly asymmetric cell type relies upon a tightly orchestrated network of proteinsRead more