New York University

Biomarker Discovery and Validation for Fragile X Syndrome

FRAXA Research Foundation 2015 Grants • 2016 Grants • Bhattacharya, Aditi • Biomarkers • Klann, Eric • New York University • Research Grant Results March 24, 2017October 10, 2019mTOR, NIH

With a $120,000 grant from FRAXA Research Foundation over 2015-2016, Dr. Eric Klann of New York University investigated potential new biomarkers in Fragile X syndrome and how to translate these markers from mouse models to human patients.

The mTOR Pathway in Fragile X Syndrome

FRAXA Research Foundation 2012 Grants • 2013 Grants • Bhattacharya, Aditi • Klann, Eric • New York University • Research Grant Results • Treatment Targets September 6, 2013February 17, 2021autism, mTOR

With a $90,000 grant from FRAXA Research Foundation over 2012-2013, Dr. Eric Klann and Postdoctoral Fellow Dr. Aditi Bhattacharrya of New York University investigated alterations in the mTOR pathway in Fragile X syndrome – which is also known to be defective in several forms of autism. Their work was published in September 2012 and received international attention.

In Vivo Imaging of Synaptic Abnormalities in a Mouse Model of Fragile X Syndrome

FRAXA Research Foundation 2006-2010 Grants • Completed Research Grants • Disease Mechanisms • Gan, Wen-Biao • New York University February 14, 2008August 5, 2021

With an $85,000 grant from FRAXA Research Foundation over 2007-2008, Dr. Wen-Biao Gan and his team at New York University studied in-vivo protein development using imaging in mouse models to determine when pre- and postsynaptic structural plasticity occurs to target and when it develops abnormally.

Examining the Amygdala in Mouse Models of Fragile X

FRAXA Research Foundation 2006-2010 Grants • Completed Research Grants • Disease Mechanisms • LeDoux, Joseph • New York University • Treatment Targets February 13, 2006December 12, 2019amygdala

With a $63,000 grant from FRAXA Research Foundation in 2006, Dr. Joseph LeDoux and his team at New York University studied the role of the amygdala in Fragile X syndrome using mouse models.