Effects of Alternative Splicing at FMR1 Exon 15 on Understanding Fragile X Syndrome

Effects of Alternative Splicing at FMR1 Exon 15 on Understanding Fragile X Syndrome

With a $118,500 grant from FRAXA Research Foundation from 2007-2008, Dr. Robert Denman and his team at the New York State Institute for Basic Research studied protein splicing, specifically looking at exon 15-encoded residues of of FMPR.

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The Molecular Basis of Increased Seizure Severity in the Fragile X Knockout Mouse

With a $50,000 grant from FRAXA Research Foundation from 2002-2003, Dr. Carl Dobkin and his team at the New York Institute for Basic Research studied the causes for heightened seizure activity in Fragile X mice. Results published.

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Prospects For Gene Therapy in the Fragile X

With a $90,000 grant from FRAXA Research Foundation from 2000-2002, Dr. Mario Rattazzi at the New York State Institute for Basic Research explored gene therapy: ways to transfer the FMR1 gene across the blood-brain-barrier in normal rats and mice, and then in FMR1 knockout mice. Results published.

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Studies of the Fragile X Knock-Out Mouse: Improving Memory Reversal Testing and Treatment with AMPAkines

Studies of the Fragile X Knock-Out Mouse: Improving Memory Reversal Testing and Treatment with AMPAkines
$62,000 GrantW. Ted Brown, MD, PhD Principal Investigator Institute For Basic Research, NY 1997-1998 FRAXA Research Grant $62,000 over 2 Years To develop an improved test to show learning deficits in the FMR1 knock-out mouse model of Fragile X, and then to test the effects of experimental drugs (Ampakines) that may be effective in treating these deficits.Read more