Stylized blue brain with an orange highlighted region representing the nucleus accumbens in Fragile X syndrome research

Bridging Naturalistic Behavior and Nucleus Accumbens in Fragile X Syndrome

How do sex and gene dosage interact to shape brain function and behavior in Fragile X syndrome? The team aims to uncover why symptoms differ between males and females.

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Dysruption of Endocannabinoid Mediated Synaptic Plasticity in the Nac of FMR1 Null Mice

This team was able to establish the endocannabinoid system as a therapeutic target for Fragile X syndrome. They also showed that the system can be targeted with pharmacology.

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Endocannabinoid Mediated Synaptic Plasticity in Fragile X Mice

FRAXA-funded studies found faulty endocannabinoid signaling in Fragile X brain circuits for reward and emotion, and boosting 2-AG restored normal function.

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FRAXA Funded Research

Current Research Grants (38)