Cold Spring Harbor Laboratory Archives • Fragile X Research

Intracortical Circuitry in the Barrel Cortex of FMR1-KO Mice

FRAXA Research Foundation 2001-2005 Grants • Cold Spring Harbor Laboratory • Completed Research Grant • Disease Mechanisms • Svoboda, Karel February 22, 2005January 16, 2019

With $40,000 in funding from FRAXA Research Foundation in 2005, Dr. Karel Svoboda and his team at the Cold Spring Harbor Laboratory imaged neocortical circuits in Fragile X mice to determine the functions of the abnormal dendritic spines found in Fragile X syndrome.

FMRP Function in the Xenopus Visual System

FRAXA Research Foundation 2001-2005 Grants • Cline, Holly • Cold Spring Harbor Laboratory • Completed Research Grant • Disease Mechanisms February 27, 2004April 25, 2018mRNAs

With a $75,000 grant from FRAXA Research Foundation from 2003-2004, Dr. Holly Cline and her team at Cold Spring Harbor Labratory studied Fragile X proteins and related mRNA regulations in tadpoles.

Studies of glutamate receptor trafficking

FRAXA Research Foundation 2001-2005 Grants • Cold Spring Harbor Laboratory • Completed Research Grant • Disease Mechanisms • Zhu, Julius August 1, 2001December 11, 2019autism, glutamate

FRAXA awarded $35,000 in 2001 to Robert Malinow, PhD, Principal Investigator and Julius Zhu, PhD, FRAXA Postdoctoral Fellow at Cold Spring Harbor Laboratory. While he was a postdoctoral fellow in Dr. Malinow’s lab, Dr. Julius Zhu carried out experiments designed to define the set of proteins which are affected in Fragile X syndrome and understand how they function together. In 2002, Dr. Zhu started his own lab at the University of Virginia where he is continuing his Fragile X work with new funding from FRAXA.

Imaging of Neocortical Dendritic Spine Maturation in FMR1 Knockout Mice Using Two-Photon Laser Scanning Microscopy

FRAXA Research Foundation 1994-2000 Grants • Cold Spring Harbor Laboratory • Completed Research Grant • Disease Mechanisms • Svoboda, Karel June 16, 1999January 16, 2019

With $30,000 in funding from FRAXA Research Foundation in 1999, Dr. Karel Svoboda and his team at the Cold Spring Harbor Laboratory explored the changing nature of dendritic spine motility by imaging neocortical circuits in Fragile X mice.