Defining Functional Domains of FMRP and Uncovering its Partners via Large Scale Mutagenesis in Drosophila

Defining Functional Domains of FMRP and Uncovering its Partners via Large Scale Mutagenesis in Drosophila
With $80,000 in funding from FRAXA Research Foundation in 2005 and in 2006, Dr. Yong Zhang and his team at the Chinese Academy of Sciences developed a way to find genes that suppress the Fragile X gene. $80,000 GrantYong Zhang, PhD Principal Investigator Xinda Lin, PhD FRAXA Postdoctoral Fellow Chinese Academy of Sciences FRAXA Research Grants $40,000 (2006) $40,000 (2005) by Xinda Lin FMRP is a widely expressed RNA-binding protein involved in RNA transport and translation. Intensive studies in the last decade have demonstrated that FMRP contains four RNA binding domains, but their actual functions are mostly untested. Meanwhile, a dozen or so protein partners and hundreds of mRNA targets interacting with FMRP have been identified, but again their functions are poorly understood. It is important that the functional domains of FMRP and its interacting partners be identified and characterized in order to understand the pathogenesis of Fragile X. In the lastRead more