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FRAXA Research Foundation – Finding a Cure for Fragile X Syndrome

FRAXA Research Foundation – Finding a Cure for Fragile X Syndrome

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FRAXA Funded Research

Research Type

Researcher

Research Organization

Grant Year

2012 Grants

Reward Function in Fragile X Syndrome

FRAXA Research Foundation September 2, 2012March 3, 2025
Christopher Cowan, PhD

With a $82,500 grant from FRAXA Research Foundation in 2011-2012, Dr. Christopher Cowan and Dr. Laura Smith explored the role of specific signaling pathways in drug-related behavioral deficits, including determining the role, if any, of known impairments in the Fragile X brain.

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A Metabolomic Drug Efficacy Index to Test Treatments in the Fragile X Mouse

FRAXA Research Foundation September 1, 2012March 3, 2025

Dr. Davidovic has been examining changes in metabolism in various brain regions that are affected in Fragile X patients. She has defined a brain-specific metabolic signature of FXS and is testing treatment strategies to restore normal levels of these metabolites.

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In Vitro Coherent Network Activity

FRAXA Research Foundation February 22, 2012March 20, 2025
Juan Bacigalupo

With a $90,000 grant from FRAXA Research Foundation from 2011-2012, Dr. Juan Bacigalupo at the University of Chile studied the abnormal network dynamics of the brain in Fragile X mice to provide information for future therapeutic drug screening.

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Role of JNK in FMRP Regulated Translation in Fragile X Syndrome

FRAXA Research Foundation January 31, 2012March 20, 2025

With a $90,000 grant from FRAXA Research Foundation over 2 years, Dr. Michael Wilhelm and his team at the University of Wisconsin studied a protein known as JNK, which is observed to be abnormally regulated in Fragile X. Like FMRP, it is involved in regulating dendritic protein synthesis, and so it may be a target for drug therapy in Fragile X.

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Serotonergic Rescue of Synaptic Plasticity in FMR1 Knockout Mice

FRAXA Research Foundation January 31, 2012March 17, 2025

With $306,000 in grants from FRAXA Research Foundation, Dr. Julius Zhu from the University of Virginia examined the effects of several drugs such as Buspar and Abilify which manipulate specific serotonin receptors and the effect that has on synaptic plasticity (LTP and LTD).

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