Linda Crnic, PhD, at University of Colorado, FRAXA research grant

Treatment of a Mouse Model of Fragile X Syndrome with MPEP

January 1, 2003

A $49K FRAXA grant helped Dr. Linda Crnic’s Colorado team study chronic MPEP use to ease Fragile X symptoms while preserving cognition.

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Structure of FMRP

February 27, 2002

With $68K from FRAXA, Dr. Lynne Regan at Yale studied how protein shapes influence Fragile X function. Results were published.

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Prospects For Gene Therapy in the Fragile X

February 27, 2002

FRAXA-funded Dr. Rattazzi explored gene therapy to transfer the FMR1 gene into the brain of Fragile X mice, publishing key results.

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Kevin Moses, PhD, Wellcome Trust, FRAXA scientific Advisor

A Genetic Screen For Dominant Modifiers of Drosophila (Fruitfly) FMR

February 27, 2002

A $35K FRAXA grant supported Dr. Kevin Moses at Emory in using fruit flies to screen for genes active in the Fragile X signaling pathway.

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Robert Malinow, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Studies of glutamate receptor trafficking

August 1, 2001

With $35K from FRAXA, Drs. Malinow and Zhu at Cold Spring Harbor mapped proteins affected by Fragile X. Dr. Zhu continued this work at UVA.

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Robert Darnell, MD, PhD, at Rockefeller University, FRAXA research grant

Identification of Specific RNA Targets of FMRP

February 27, 2001

FRAXA-funded Dr. Darnell’s Rockefeller team uncovered how FMRP works and how its absence alters brain function. Published results.

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Dr. Eric Kandel, MD, Columbia University, FRAXA research grant

Transgenic Mouse Model Studies of Fragile X Syndrome

February 27, 2001

With $410K from FRAXA, Dr. Eric Kandel’s team at Columbia developed Fragile X mouse models to advance future studies of the disorder.

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Startle Modulation in Males with Fragile X Syndrome

February 27, 2001

FRAXA’s $42,720 grant helped Dr. Elisabeth Dykens uncover startle and PPI effects in Fragile X males. Results were published.

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Claudia Bagni, PhD, at University of Rome, FRAXA research grant

Molecular Interactions Between FMRP and Protein Translation Apparatus

February 27, 2001

FRAXA-funded Dr. Bagni uncovered how Fragile X disrupts protein synthesis control, advancing molecular understanding. Published results.

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Justin Fallon, PhD, Brown University, FRAXA research grant

Transcriptional Regulation of the Fragile X Gene (fmr1) in the Olfactory Bulb

January 9, 2001

With $35K from FRAXA, Dr. Justin Fallon’s team at Brown University mapped Fragile X granules and explored FMRP’s role in sensorimotor function.

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FRAXA Funded Research

Current Research Grants (38)