Imaging of Neocortical Dendritic Spine Maturation in FMR1 Knockout Mice Using Two-Photon Laser Scanning Microscopy

Imaging of Neocortical Dendritic Spine Maturation in FMR1 Knockout Mice Using Two-Photon Laser Scanning Microscopy

With $30,000 in funding from FRAXA Research Foundation in 1999, Dr. Karel Svoboda and his team at the Cold Spring Harbor Laboratory explored the changing nature of dendritic spine motility by imaging neocortical circuits in Fragile X mice.

Karel Svoboda, PhD, at Cold Spring Harbor Laboratory, FRAXA research grantRead more

Studies of the Fragile X Knock-Out Mouse: Improving Memory Reversal Testing and Treatment with AMPAkines

Studies of the Fragile X Knock-Out Mouse: Improving Memory Reversal Testing and Treatment with AMPAkines

A two year $62,000 FRAXA grant was been awarded to W. Ted Brown, MD, PhD from 1997-1998. The Principal Investigator at the Institute For Basic Research in New York will work to develop an improved test to show learning deficits in the FMR1 knock-out mouse model of Fragile X, and then to test the effects of experimental drugs (Ampakines) that may be effective in treating these deficits.

W Ted Brown, MD, PhDRead more