Postsynaptic Density 95 (PSD-95) Archives • FRAXA Research Foundation

Autophagy is a Novel Therapeutic Target of Impaired Cognition in Fragile X Syndrome

December 27, 2018

FRAXA’s $90K grant enabled Dr. Zukin to link impaired autophagy to Fragile X. Boosting autophagy restored synaptic proteins and reversed cognitive deficits in mice.

How Promising is CRISPR for Fragile X?

August 14, 2018

FRAXA Investigator Peter Todd, MD, PhD, tells us about CRISPR in Fragile X research, how realistic is it that it could turn the Fragile X gene back on, and if it can really cure Fragile X.

Bryostatin Restores Learning and Memory in Adult Fragile X Mice

March 11, 2015

A marine critter found off the California coast — Bugula neritina — is the only source of Bryostatin. Bryostatin-1 restores spatial learning and memory in adult Fragile X mice.

Role of Experience in Regulating Levels of the Fragile X Protein

January 1, 2004

With $49K in grant funding from FRAXA, Drs. Mack and Todd studied how neuronal activity — such as seizures or environmental stimulation — changes FMRP levels. Results published.

Autophagy is a Novel Therapeutic Target of Impaired Cognition in Fragile X Syndrome

How Promising is CRISPR for Fragile X?

Bryostatin Restores Learning and Memory in Adult Fragile X Mice

Role of Experience in Regulating Levels of the Fragile X Protein

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