NMDA Archives

High-resolution image of dendritic spines—tiny structures on neurons that are altered in Fragile X syndrome.

New Research Targets NMDA Receptor – A Key Player in Brain Communication and Fragile X Syndrome

April 30, 2025

Fragile X syndrome research identifies NMDA receptor as a promising treatment target, with drugs already in trials offering faster paths to human studies.

Developmental Profile of Glutamatergic Synapses in Fragile X

May 2, 2019

A FRAXA fellowship helped reveal how glutamate receptors at synapses develop differently in Fragile X, offering clues to improve learning and memory.

Enhancing NMDA Receptor Signaling to Treat Fragile X Syndrome

March 7, 2019

FRAXA-backed work revealed NMDA receptors may hold the key to correcting brain signaling in Fragile X, pointing to new treatment strategies.

Enhancement of NMDA Receptor Signaling for the Treatment of Fragile X Syndrome

August 15, 2016

Drs. Emily Osterweil and Stephanie Barnes investigated NMDA receptor signaling and how rebalancing protein synthesis could correct Fragile X brain abnormalities.

FRAXA funds 1 million in Fragile X research

Fragile X Cure One Step Closer with FRAXA Support of $1 Million in New Research

April 26, 2016

4 Countries – 10 Teams – $1 Million for finding new treatment targets, to pinpointing outcome measures for future clinical trials, to attempting to reactivate the gene which is silenced in Fragile X syndrome, these innovative scientists will bring us closer to a cure.

Seizures in Fragile X Syndrome and Therapeutic Potential of NMDA Receptor Antagonists

September 8, 2014

Dr. Wong studies how NMDA and mGluR receptors interact to trigger seizures in Fragile X, revealing NR2B-specific blockers as a promising targeted treatment.

Social Behavior as an Outcome Measure for Fragile X Clinical Trials

September 13, 2013

FRAXA funding helped identify reliable social behavior tests in Fragile X mice and showed an mGluR5 treatment could improve sociability, guiding future trials.

New Research Targets NMDA Receptor – A Key Player in Brain Communication and Fragile X Syndrome

Developmental Profile of Glutamatergic Synapses in Fragile X

Enhancing NMDA Receptor Signaling to Treat Fragile X Syndrome

Enhancement of NMDA Receptor Signaling for the Treatment of Fragile X Syndrome

Fragile X Cure One Step Closer with FRAXA Support of $1 Million in New Research

Seizures in Fragile X Syndrome and Therapeutic Potential of NMDA Receptor Antagonists

Social Behavior as an Outcome Measure for Fragile X Clinical Trials

Support FRAXA

Get In Touch!

Explore Fragile X & Research

Get FRAXA Updates