Sex Differences and the Role of Estrogen Receptors in Fragile X

Fragile X syndrome researchers are studying how estrogen receptors shape brain activity and may explain why males and females experience symptoms differently.

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Mega Green Tea Extract to Treat Fragile X?

FRAXA funded a clinical trial of EGCG (green tea extract) on cognitive function in adults with FXS. The team in Barcelona reported memory, attention, and mental flexibility improvements.

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Mara Dierssen, MD, PhD

Phase 1 Clinical Trial of Mega Green Tea Extract in Fragile X Syndrome

An early trial of green tea extract EGCG improved cognition in Fragile X. It targets ERβ and reduces overactive PI3K/mTOR/ERK signaling linked to FXS symptoms.

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FRAXA Funded Research

Current Research Grants (38)