estrogen Archives • Fragile X Research - FRAXA Research Foundation

Mega Green Tea Extract to Treat Fragile X?

Hannah Maria Miles de la Torre, Rafael • Dierssen, Mara • Research Updates August 22, 2018Alzheimer's, estrogen

Green tea is thought to have many benefits, particularly in cognitive function. In 2012-14, FRAXA Research Foundation funded a clinical trial to assess the effects of EGCG (green tea extract) on cognitive function in adults with FXS. Drs. Rafael de la Torre and Mara Dierssen Sotos, principal researchers in Barcelona, Spain, reported many positive results. After the extract was no longer administered, effects remained stable. Memory, attention, and mental flexibility improvements were still observable at least 3 months after treatment ended.

Studies of Mega Green Tea Extract to Treat Fragile X Syndrome

FRAXA Research Foundation 2012 Grants • 2013 Grants • 2014 Grants • Biomarkers • Centre for Genomic Regulation • Clinical • Clinical Trials • Completed Research Grant • de la Torre, Rafael • Dierssen, Mara September 13, 2014August 2, 2018ERK, estrogen, mTOR

With a $124,000 grant from the FRAXA Research Foundation from 2012-2014, Dr. Mara Dierssen and Dr. Rafael de la Torre conducted preclinical studies in Fragile X knockout mice and a clinical trial in Fragile X patients using Mega Green Tea Extract, which contains 45% by weight epigallocatechin gallate (EGCG).