Robert Wong, PhD

Seizures in Fragile X Syndrome and Therapeutic Potential of NMDA Receptor Antagonists

Dr. Wong studies how NMDA and mGluR receptors interact to trigger seizures in Fragile X, revealing NR2B-specific blockers as a promising targeted treatment.

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Social Behavior as an Outcome Measure for Fragile X Clinical Trials

FRAXA funding helped identify reliable social behavior tests in Fragile X mice and showed an mGluR5 treatment could improve sociability, guiding future trials.

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Kendal Broadie

Matrix Metalloproteinase Therapeutic Treatments for Fragile X Syndrome

Dr. Broadie showed that MMP enzymes disrupt synapse development in Fragile X. MMP inhibitors (e.g. minocycline) improved connectivity and behavior in fruit flies.

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FRAXA Funded Research

Current Research Grants (39)