Human FMR1 Isoform-Specific Regulation of Translation and Behavior

Human FMR1 Isoform-Specific Regulation of Translation and Behavior

Fragile X syndrome is caused by lack of one protein, FMRP. But this one protein occurs in different variations. Do the different versions of FMRP have different roles in the brain, and if so, is there one that’s key? If we could replace FMRP to treat Fragile X syndrome, which version would we use?

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