Bassell, Gary Archives • Fragile X Research

Spectrum News – Newly Discovered Aspects of Fragile X Spur Next Wave of Drugs

FRAXA Research Foundation Bassell, Gary • Bear, Mark • FRAXA Updates • Osterweil, Emily • Research Updates • Zhao, Xinyu September 27, 2018October 19, 2018lovastatin, mGluR, mTOR

Many drugs for fragile X syndrome have failed in large clinical trials, but candidates that target new aspects of the condition may fare better.

Genetic and Pharmacologic Manipulation of PI3K Activity in FXS: Assessing Potential Therapeutic Value

FRAXA Research Foundation 2011 Grants • 2012 Grants • Bassell, Gary • Completed Research Grant • Disease Mechanisms • Emory University • FRAXA Research Grants • Gross, Christina • Muddashetty, Ravi • Treatment Targets September 2, 2012August 3, 2018cancer, mRNAs, mTOR

With a $90,000 grant from the FRAXA Research Foundation, Dr. Gary Bassell and his team at Emory University explored the PI3K/mTOR signaling complex in FXS via genetic and pharmacologic rescue approaches, to reduce the enzymatic function of specific components of this complex pathway in an FXS mouse model.