State University of New York

Seizures in Fragile X Syndrome and Therapeutic Potential of NMDA Receptor Antagonists

FRAXA Research Foundation 2013 Grants • 2014 Grants • Completed Research Grants • Disease Mechanisms • Drug Repurposing • State University of New York • Treatment Targets • Wong, Robert , , , ,
Seizures in Fragile X Syndrome and Therapeutic Potential of NMDA Receptor Antagonists

With a $90,000 grant from the FRAXA Research Foundation, Dr. Robert Wong is investigating how seizures are generated in Fragile X neurons. More generally, he is looking at how synapses are modified to enable learning and memory and how this process is impaired in Fragile X.

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The Role of FMRP and Small, Non-Coding RNAs in Translation

FRAXA Research Foundation 2006-2010 Grants • Completed Research Grants • State University of New York • Tiedge, Henri • Treatment Targets • Zhong, Jun , ,
The Role of FMRP and Small, Non-Coding RNAs in Translation

With a $120,000 grant from FRAXA Research Foundation, Drs. Henri Tiedge and Jun Zhong studied the mechanisms by which local protein translation is repressed. Multiple parallel mechanisms keep protein synthesis in check; one of them involves FMRP, and a similar mechanism involves the non-coding RNA, BC1. Results published.

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