New York State Institute for Basic Research Archives • FRAXA Research Foundation

Effects of Alternative Splicing at FMR1 Exon 15 on Understanding Fragile X Syndrome

February 14, 2008

FRAXA-funded research by Dr. Robert Denman explored how exon 15 affects FMRP protein splicing—offering insights into Fragile X molecular mechanisms.

February 26, 2003

FRAXA’s $50K grant supported Dr. Carl Dobkin’s team in uncovering why Fragile X mice show increased seizure activity. Findings published.

January 14, 2003

With $60K from FRAXA, Dr. Denman’s team investigated how the Fragile X protein FMRP functions in the brain.

February 27, 2002

FRAXA-funded Dr. Rattazzi explored gene therapy to transfer the FMR1 gene into the brain of Fragile X mice, publishing key results.

June 27, 1998

FRAXA-funded Dr. W. Ted Brown studied learning deficits in Fragile X mice and tested Ampakine drugs for potential treatment.