Roles of Postnatal Transient Connectivity in the Development of Fragile X Syndrome

August 9, 2023

This team is studying why people with Fragile X are overly sensitive to sound and light, using advanced imaging to find brain changes and test ways to prevent them.

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Karel Svoboda, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Intracortical Circuitry in the Barrel Cortex of FMR1-KO Mice

February 22, 2005

With $40K from FRAXA, Dr. Karel Svoboda at Cold Spring Harbor imaged brain circuits in Fragile X mice to study abnormal dendritic spines.

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Holly Cline, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

FMRP Function in the Xenopus Visual System

February 27, 2004

With $75K from FRAXA, Dr. Holly Cline at Cold Spring Harbor studied Fragile X proteins and mRNA regulation in tadpoles.

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Robert Malinow, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Studies of glutamate receptor trafficking

August 1, 2001

With $35K from FRAXA, Drs. Malinow and Zhu at Cold Spring Harbor mapped proteins affected by Fragile X. Dr. Zhu continued this work at UVA.

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Karel Svoboda, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Imaging of Neocortical Dendritic Spine Maturation in FMR1 Knockout Mice Using Two-Photon Laser Scanning Microscopy

June 16, 1999

With $30K from FRAXA, Dr. Karel Svoboda’s team at Cold Spring Harbor studied dendritic spine changes in Fragile X mouse brain circuits.

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FRAXA Funded Research

Current Research Grants (38)