PAK (p21-activated kinase) Archives • Fragile X Research

Synaptic Actin Signaling Pathways in Fragile X

FRAXA Research Foundation 2006-2010 Grants • 2012 Grants • Completed Research Grants • Disease Mechanisms • Duke University • FRAXA Research Grants • Kim, Hwan • Soderling, Scott September 11, 2012April 25, 2018CYFIP, mGluR, mRNAs, PAK (p21-activated kinase)

With a $163,356 grant from FRAXA Research Foundation in 2010-12, Dr. Scott Soderling and Dr. Hwan Kim at Duke University bred the standard mouse model of Fragile X syndrome to their lines of mice that express reduced levels of several key proteins that modulate synaptic actin. These compound mutant mice were compared to FXS mice to determine if genetically impairing pathways to the actin cytoskeleton can rescue deficits in the FXS mice.

Experimental Compound FRAX486 Reverses Signs of Fragile X in Mice

FRAXA Research Foundation 2001-2005 Grants • 2006-2010 Grants • Completed Research Grants • Disease Mechanisms • Massachusetts Institute of Technology (MIT) • Tonegawa, Susumu February 13, 2006April 25, 2018PAK (p21-activated kinase)

With an $81,000 grant from FRAXA Research Foundation from 2005-2006, Dr. Susumu Tonegawa and his team at MIT studied the enzyme PAK to determine how it could be used for a treatment target. Results published.