DoD Archives

Towards Understanding the Role of FMRP in Human Brain Development Using Brain Organoids

FRAXA Research Foundation Jin, Peng • Seminar Series • Wen, Zhexing December 8, 2020December 8, 2020autism, cancer, DoD, epigenetics, FXPOI, FXTAS, mRNAs, NIH, organoid

Dr. Zhexing Wen and Dr. Peng Jin of the newly funded Fragile X Center of Excellence at Emory University School of Medicine join us in this seminar to present about Understanding the Role of FMRP in Human Brain Development Using Brain Organoids.

Department of Defense Medical Research Funding Guided by FRAXA Consumer Reviewers

FRAXA Research Foundation Advocacy November 17, 2020DoD, PRMRP

FRAXA nominated three individuals to join in the program this year. Over the past several weeks, Katie Clapp, Ellen Skala, and Jennifer Frobish participated in the evaluation of research applications submitted to the PRMRP. As consumer reviewers, they were full voting members (along with prominent scientists) at meetings to help determine how the $360 million appropriated by Congress for Fiscal Year 2020 will be spent on PRMRP research.

Mechanisms and Biomarkers of Sensory Hypersensitivity in the fmr1 Knockout Mouse

FRAXA Research Foundation Binder, Devin • Razak, Khaleel • Research Updates • Seminar Series August 27, 2020August 27, 2020astrocytes, DoD, drug repurposing, EEG, glutamate, Healx, hypersensitivity, matrix metalloproteinase, NIH, seizure, sound

In this Fragile X research webinar we hear from Devin K. Binder, MD, PhD, Professor, University of California at Riverside Medical School and Khaleel Razak, PhD, Professor, University of California at Riverside as they present about Mechanisms and Biomarkers of Sensory Hypersensitivity in the fmr1 Knockout Mouse.

Federal Funding for Fragile X Research Faces Snags

Katie Clapp Advocacy February 21, 2019June 5, 2019DoD, NIH

We in the Fragile X community have our advocacy work cut out for us to restore levels of federal funding for Fragile X research! Both of the main federal funders – the National Institutes of Health (NIH) and the Department of Defense (DOD) are letting Fragile X research lapse!

Fragile X Fruit Fly Research Bears Fruit

FRAXA Research Foundation Jongens, Tom • McBride, Sean • Research Updates April 26, 2016December 26, 2019autism, DoD, fruit fly, metformin, NIH, sleep

A new FRAXA-funded study shows how the hormone insulin – usually associated with diabetes — is involved in the daily activity patterns and learning deficits in the fruit fly model of Fragile X Syndrome (FXS). The study also reveal a metabolic pathway that can be targeted by new and already approved drugs to treat Fragile X patients, notably metformin.