channelopathy Archives • Fragile X Research

Inherited Channelopathies in Cortical Circuits of Fmr1 KO Mice

FRAXA Research Foundation 2006-2010 Grants • 2011 Grants • Disease Mechanisms • Frick, Andreas • Neurocentre Magendie, France • Research Grant Results • Treatment Targets August 22, 2012May 17, 2020autism, channelopathy, hyperexcitability, hypersensitivity, ion channel, mRNAs, seizure

With this two year award of $90,000, Dr. Zhang and Principal Investigator Dr. Andreas Frick at Neurocentre Magendie in France investigated channelopathies using Fragile X mice. Many other proteins are misregulated as a result of the absence of FMRP. It is known that many ion channels, the pores in the cell membrane which allow neurons to conduct electrical impulses, have altered levels in Fragile X. This state is sometime called a “channelopathy” in the pharma world. This group is studying the effect of specific alterations in ion channels, and potential therapeutic effects of drugs which open and close these channels.

Channelopathies: Altered Ion Channels in Fragile X Syndrome

FRAXA Research Foundation 2006-2010 Grants • 2011 Grants • Brager, Darrin • Completed Research Grants • Disease Mechanisms • Johnston, Daniel • Treatment Targets • University of Texas at Austin September 15, 2011May 17, 2020BK channel, channelopathy, ion channel, potassium channels

With a $95,000 grant from FRAXA Research Foundation from 2010-2011, Dr. Daniel Johnston and Dr. Darrin Brager at the University of Texas at Austin investigated alterations in ion channels in Fragile X syndrome. They explored potential therapeutic effects of drugs which open and close these channels. Results published.