FRAXA Announces 2012 Fragile X Research Awards
2012 Fragile X Research Awards Total $1,132,923
$1,132,923 in New Program Grants, Postdoctoral Fellowships, and Renewals have been approved for the next year. We are funding over $846,000 in new projects; renewals total $285,678 and will increase as additional projects reach their one year mark.
In Vitro Coherent Network Activity
This work revealed that Fragile X neurons form disordered network dynamics—laying groundwork for using network activity as a treatment-screening metric.
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Role of JNK in FMRP Regulated Translation in Fragile X Syndrome
JNK kinase is abnormally active in Fragile X model mice and directly regulates mGluR-dependent translation of FMRP targets, pointing to JNK as a therapeutic target.
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Serotonergic Rescue of Synaptic Plasticity in FMR1 Knockout Mice
Dr. Zhu examined how serotonin-targeting drugs such as Buspar and Abilify influence synaptic plasticity, including LTP and LTD.
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