Sean McBride, MD, PhD
Rowan University Medical School
with Tom Jongens, PhD, and Catherine Choi, PhD, Co-Investigators
$240,000 in 2008-09
$140,000 in 2005-06
One of the most important aspects of FRAXA’s research is the preclinical validation of potential therapeutic strategies. Many labs have found new leads for treatment. However, very few have the capacity to test new drugs in the mouse model to establish efficacy rigorously enough to lead to clinical trials. The McBride lab (in a broad collaboration with the Choi, Jongens, and Skoulakis groups) aims to do just that.
Examining Cognitive Dysfunction in the Drosophila Model of Fragile X Syndrome
Fragile X Syndrome is the most common inherited form of mental retardation, but few medications exist to help Fragile X patients. In a fruit fly model of the disease, researchers from the University of Pennsylvania School of Medicine and their colleagues have shown that it is possible to reverse some of the symptoms of the disorder using drugs that dampen specific neuronal overactivity. Their findings appeared in the March 3, 2005 issue of Neuron, and in Newsweek Magazine.
With further funding from FRAXA, Sean McBride and colleagues performed biochemical studies to investigate the effects of these treatments on levels of relevant proteins, to fully understand how the drugs are having their effects. They will evaluate learning and memory of aged fruit flies to determine if prolonged treatments that restore memory in young adulthood continue to be effective in elderly flies. Already they have preliminary evidence of increased cognitive deficits in older fragile X flies and that these deficits can be prevented with drug treatments.
They also tested the effects of these treatments in FMR1 knockout mice, specifically studying the effects of mGluR antagonists, lithium, and other drugs on the enhanced mGluR-dependent long-term depression phenotype in the fragile X mice.